Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous keukemia
Article Abstract:
Results demonstrate that chronic myelogenous leukemia patients with bone marrow transplant or interferon-alpha2b or chemotherapy treatment, develop a proteinase 3-derived peptide PR1 suggesting that T lymphocytes conferred immunity is involved in the removal of malignant cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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Ex vivo identification, isolation and analysis of tumor-cytolytic T cells
Article Abstract:
Research demonstrates isolation of tumor-cytolytic T cells directly from patient blood samples following cancer vaccination. Direct correlation between antigen specificity and cytolytic activity, at a single-cell level, is made by surface mobilization coupled with peptide-major histocompatibility complex tetramer staining. Expansion of tumor-cytolytic T cells ex vivo is presented.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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Characterization of circulating T cells specific for tumor-associated antigens in melonoma patients
Article Abstract:
Circulating T cells specific for tumor-associated antigens (TAAs) in melanoma patients have been characterized. Circulating CD8(super.+) T-cell populations specific for the TAAs MART-1 (27-35) or tyrosinase (368-376) have been identified in six of eleven patients with metastatic melanoma using peptide/HLA-A(super.*)0201 tetramers.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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