Expression of inflammatory cytokines (interleukin-1beta and interleukin-6) in amniochorionic membranes
Article Abstract:
Fetal membranes appear to be a source of of interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) as well as the lining cells of the uterus. These substances mediate inflammatory processes, including the stimulation of labor in the presence of intrauterine infection. Fetal membranes were collected from both infected and uninfected women at delivery and analyzed under the microscope for the presence and location of IL-6 and IL-1beta. Membranes from uninfected women were cultured and exposed to endotoxin, a substance secreted by infectious bacteria. IL-1beta production increased in the presence of infection, but it was present in the absence of infection. IL-6 was only produced in response to infection. IL-1beta was manufactured only in the chorion layer, but IL-1beta itself was found in both the amnion and chorion. IL-6 manufacture took place in both layers, and IL-6 was also found in both layers.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
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Inflammatory cytokine (interleukins 1, 6, and 8 and tumor necrosis factor-alpha) release from cultured human fetal membranes in response to endotoxic lipopolysaccharide mirrors amniotic fluid concentrations
Article Abstract:
The innermost membrane surrounding the fetus may be the source of inflammatory proteins released in response to infection and that precipitate preterm labor. Researchers obtained membrane sacs from women who had elective cesarean deliveries not due to infection. Membranes were exposed to bacteria in the laboratory, and inflammatory protein levels were measured. The infected membranes released interleukins 1, 6, and 8 and tumor necrosis factor-alpha. Interleukin-6 and -8 were released in greater quantities than the other two proteins. Interleukin-6 has the closest association with the inflammatory response to infection leading to preterm labor.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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Collagenolytic enzymes (gelatinases) and their inhibitors in human amniochorionic membrane
Article Abstract:
The activity of two enzymes found in the amniotic sac called gelatinase A and gelatinase B may contribute to some premature membrane ruptures involving infection. Gelatinase A and gelatinase B activity was measured in amniotic membrane samples from women with amniotic infections and from normal cesarean deliveries (control samples). Gelatinase A was expressed in both samples. Gelatinase B activity was seen only in infected membrane samples. However, infectious stimulation resulted in gelatinase B activity in the control samples. Natural inhibitors of both enzymes were found under all conditions.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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