Extensive platelet activation in preeclampsia compared with normal pregnancy: enhanced expression of cell adhesion molecules
Article Abstract:
Higher levels of circulating blood platelets may be activated in preeclamptic pregnancies than in normal pregnancies. Preeclampsia is a serious complication of pregnancy that can lead to maternal death. Researchers analyzed the activation of platelets in whole blood samples from 10 women with preeclampsia and from 10 women with normal third-trimester pregnancies. Circulating platelet activation was greater in all 10 women with preeclampsia as compared to four of 10 women with normal pregnancies. Greater expression of platelet endothelial cell adhesion molecule-1 was found in preeclamptic women and may be a useful indicator of preeclampsia.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Can flow cytometric detection of platelet activation early in pregnancy predict the occurrence of preeclampsia? A prospective study
Article Abstract:
Levels of a blood platelet antigen called CD63 appear to be one distinguishing feature of pregnant women at risk for preeclampsia. This antigen is a marker for platelet activation. Pregnancy complications were documented and blood levels of CD63, CD62P, and CD31 were measured in 244 pregnant women. Nearly 7% of the participants developed preeclampsia. Women with increased CD63 levels during the first trimester were nearly twice as likely to later develop preeclampsia. Women with elevated blood pressure and increased CD63 levels during the first trimester were more than nine times more likely to develop preeclampsia.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Clearance of cervical human papillomavirus infection by treatment for cervical dysplasia
Article Abstract:
Human papillomavirus (HPV) infections frequently found in patients with cervical dysplasia often disappear after treatment for the dysplasia. Ninety-one patients treated for cervical dysplasia were tested for HPV before and after treatment. Nearly all of the patients were HPV-positive before treatment while only 31% were HPV-positive after treatment. Only nine patients were infected with the same HPV strain before and after treatment. Many of the patients with persistent HPV infections after treatment either had only part of the cervix removed or also had HIV infections.
Publication Name: Sexually Transmitted Diseases
Subject: Health
ISSN: 0148-5717
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Platelet intracellular free calcium response to arginine vasopressin is similar in preeclampsia and normal pregnancy
- Abstracts: Resistance to activated protein C as a basis for venous thomboembolism associated with pregnancy and oral contraceptives
- Abstracts: Induction of labor compared with expectant management for prelabor rupture of the membrane at term. Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss
- Abstracts: Disseminated Penicillium marneffei infection associated with human immunodeficiency virus: a report of two cases and a review of 35 published cases
- Abstracts: A comparison of endothelium-dependent relaxation in omental and myometrial resistance arteries in pregnant and nonpregnant