Recombinant erythropoietin for the treatment of anemia in inflammatory bowel disease

Article Abstract:

Therapy with iron and recombinant erythropoietin appears to raise hemoglobin levels in anemic patients with inflammatory bowel disease resistant to iron and vitamin therapy. Researchers administered oral doses of iron and injections of recombinant erythropoietin, a synthetic hormone that stimulates red blood cell production, to 17 patients with ulcerative colitis or Crohn's disease. A second group of 17 patients received iron and placebo medication (the control group). After 12 weeks of treatment, hemoglobin levels had risen more than 1.0 gram per deciliter among 82% of the erythropoietin group, compared to 24% among the control group. Excessive decreases in hemoglobin levels, defined as treatment failure, occurred in five control patients and two erythropoietin patients. Treating anemic patients may be more difficult due to a relative deficiency of erythropoietin.

Evaluation, Measurement, Drug therapy, Hemoglobin, Hemoglobins, Inflammatory bowel diseases, Erythropoietin, Recombinant, Recombinant erythropoietin, Iron deficiency anemia

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Inflammatory skin diseases, T cells, and immune surveillance

Article Abstract:

Research continues to elucidate the involvement of certain T cells in some skin diseases. T cells are one of the primary defenses against dangerous microorganisms. When the skin is injured, a microorganism on the surface of the skin could enter the bloodstream. Consequently, there is a group of T cells in lymph nodes near the skin that collect at skin injuries to prevent infection. They are called CLA T cells because they have a protein on their surface called the cutaneous lymphocyte antigen (CLA). However, these cells also seem to be involved in some inflammatory skin diseases.

Health aspects, Skin, Dermatitis, T cells

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