Familial ovarian cancer in Israeli Jewish women
Article Abstract:
Families in which ovarian cancer is common have been reported from various parts of the world. The reported risk for ovarian cancer in the general population is 1 in 70, but in these families, the risk is 1 in 6. The most common gynecologic cancer in Jewish women in Israel is ovarian cancer, and eight families with histories of ovarian cancer are described. Records were analyzed from 24 cases in the 8 families. Two members had the disease in four families, and three or more members were affected in the other four families. In five families, siblings were involved, and transmission between generations (lineal) was seen in six families. Both sibling and lineal cases were seen in three families. Seven families were European in ancestry, while one was Asian. The ovaries were removed as a preventive measure in five healthy close relatives and an ovarian tumor was found unexpectedly in one patient. Such prophylactic removal may not prevent the spread of the malignancy, as hidden cancerous cells may already have spread to other abdominal regions prior to surgery. The abdominal cavity should be thoroughly explored for abnormalities at the time of surgery. Breast cancer was also diagnosed in the daughters of two patients. The incidence of this disease has been noted in other research to be increased in ovarian cancer-prone families. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Obstetrics and Gynecology
Subject: Health
ISSN: 0029-7844
Year: 1991
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The management of pseudomyxoma peritonei
Article Abstract:
Pseudomyxoma peritonei is associated with mucinous neoplasms (tumors containing a protein found in mucus) located in the peritoneal, or abdominal, cavity. The tumors most often originate from the ovary or appendix, and the original neoplasms may be benign, borderline, or malignant. Pseudomyxoma peritonei is characterized by peritoneal implants with columnar epithelium and mucin. Spread of the neoplastic cells outside the peritoneal cavity is rare. A review of nine cases seen over a nine-year period indicates that chemotherapy is ineffective. The patients have distention of the abdomen, and eventually the accumulation of mucin is so great that the encased bowel cannot function. Surgical intervention is necessary to relieve the bowel obstruction, and is the standard treatment. Many patients require repeated aggressive surgery for clearance of the mucinous tumor. The medical literature suggests that the five-year survival is between 40 and 50 percent; this is reflected in the current series of nine patients. Four patients have died before five years, and one at almost nine years. More than five years have passed since the diagnosis of the four remaining living patients, but only one of these four is alive with no evidence of disease. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Cancer
Subject: Health
ISSN: 0008-543X
Year: 1990
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