Fetal fibronectin, interleukin-6, and C-reactive protein are useful in establishing prognostic subcatagories of idiopathic preterm labor

Article Abstract:

The presence of certain indicators in cervical fluid and blood plasma may predict preterm labor and delivery before 34 weeks of pregnancy. Researchers studied 37 patients with preterm labor. Twenty-nine women had fetal fibronectin in the cervical fluid, and 89% of these were delivered before 34 weeks of pregnancy. Elevated plasma C-reactive protein levels were associated with high interleukin-6 levels in amniotic fluid, and seven of eight women with the latter marker did not respond to attempts to stop labor with drugs. Women with both fetal fibronectin and high interleukin-6 levels may not respond to attempts to stop labor, and are likely to deliver prematurely. These noninvasive tests may reduce the need for amniocentesis to predict preterm labor and delivery.

C-reactive protein, Interleukin-6

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Cervical fetal fibronectin in patients at increased risk for preterm delivery

Article Abstract:

A new rapid test holds promise for detecting fibronectin in cervical secretions. Fibronectin in cervical secretions predicts premature labor in otherwise symptom-free women. Researchers periodically collected paired samples of cervical secretions from 102 pregnant women at risk for premature birth and tested for fibronectin using both the standard test and the new, rapid result membrane test. Thirty-eight women gave birth prematurely. The new test accurately predicted 85% of these births as well as 85% of the women who would go to full term. The positive predictive accuracy exceeded the standard test and the negative accuracy was comparable.

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The value of fetal fibronectin in cervical and vaginal secretions and of ultrasonographic examination of the uterine cervix in predicting premature delivery for patients with preterm labor and intact membranes

Article Abstract:

Measurements of the amount of fetal fibronectin in cervical secretions of pregnant women may predict which women are likely to have preterm delivery. Researchers evaluated 108 patients who were admitted to the hospital because of preterm labor. Cervical secretions with high fetal fibronectin levels were associated with preterm delivery. Fetal fibronectin levels predicted preterm delivery better than ultrasound examination of the cervix. Cervical fetal fibronectin was more sensitive than vaginal fetal fibronectin at predicting preterm delivery.

Analysis, Body fluids

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