Findings on host resistance genes for infectious diseases are pointing the way to drugs, vaccines
Article Abstract:
There appear to be many genes that can protect against disease or increase one's susceptibility to disease. The protective effect of the sickle cell form of hemoglobin against malaria has been known for many years. The African form of glucose-6-phosphate dehydrogenase deficiency also protects against malaria. Certain variations in HLA histocompatibility antigens also protect against malaria. On the other hand, a variation of the gene for tumor necrosis factor (TNF) increases the risk of malaria. Twelve other human genes have been identified that increase susceptibility to malaria. The TNF variant has also been linked to leprosy and asthma. On the other hand, a TNF variant has been found to protect against tuberculosis. Variants in the gene for the vitamin D receptor reduce the risk of tuberculosis. Research on the genetic basis for disease susceptibility could lead to effective treatments.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1996
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Fighting infectious disease threats via research: a talk with Anthony S. Fauci
Article Abstract:
The director of the National Institute of Allergy and Infectious Diseases believes that public support for and funding of basic research could help the nation respond quickly to emerging infectious diseases. In an interview with JAMA, Dr. Anthony S. Fauci said he wants to strengthen collaboration between the government agency and private companies, particularly pharmaceutical companies. He cited the government-industry partnership that developed the acellular pertussis vaccine. Fauci does not agree with proposed government regulations that would limit the prescribing of antibiotics, which have been linked to the emergence of antibiotic-resistant microorganisms. Instead, he wants to develop practice guidelines for physicians on the proper use of antibiotics.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1996
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Alzheimer disease experts advise a 'wait for the data' response to new diagnostic test
Article Abstract:
A test for Alzheimer's disease is being advertised in prominent medical magazines before its effectiveness has been properly studied. The test is called AD7C and is marketed by Nymox Corp. It measures the level of a brain protein called neuronal thread protein (NTP) in cerebrospinal fluid. In company tests, 87% of a group of patients with Alzheimer's disease tested positive for NTP compared to none of a matched group of healthy volunteers. However, a patient who tests negative but has the symptoms of dementia will still require additional diagnostic tests.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1997
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