Activin to the rescue for overexcited neurons

Article Abstract:

The physiological aspects of nervous system disorders that involve the overactivation of neural receptors are studied. Research presented concerns cellular signaling pathways, fibroblast growth factors, and cytokine activin A.

Physiological aspects, Cellular control mechanisms, Cell regulation, Neurons, Cytokines, Fibroblast growth factors, Nervous system diseases, Neurotransmitter receptors

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Protein twists and turns in Alzheimer disease

Article Abstract:

Research of Alzheimer disease is driven by a focus on two proteins, tau and APP, thought to underline the affliction. Brains of affected individuals accumulate aberrant forms of both of the proteins, where tau becomes hyperphosphorylated and accumulates in neuritic aggregates and APP is cleaved to produce amyloid-beta protein aggregates.

Alzheimer's disease, Proteins, Amyloid beta-protein, Protein structure

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Gamma secretase-medicated Notch signaling worsens brain damage and functional outcome in ischemic stroke

Article Abstract:

Mice transgenic for antisense Notch and normal mice treated with inhibitors of the Notch-activating enzyme Greek small letter gamma-secretase showed reduced damage to brain cells and improved functional outcome in a model of focal ischemic stroke. These findings suggest that Notch signaling might be a therapeutic target for treatment of stroke and related neurodegenerative conditions.

Stroke (Disease), Stroke, Genetically modified animals, Brain damage

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