Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti - inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis: The CLASS Study: A Randomized Controlled Trial
Article Abstract:
Celecoxib appears to have fewer gastrointestinal side effects than other non-steroidal anti-inflammatory drugs (NSAIDs), according to a study of 8,000 patients. Celecoxib belongs to a class of drugs called COX-2 inhibitors and the patients who took it were less likely to develop ulcers compared to patients taking other NSAIDs.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2000
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Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs
Article Abstract:
Misoprostol may reduce the risk for stomach and intestinal tearing, bleeding or blockage associated with nonsteroidal anti-inflammatory drugs (NSAIDS) in patients with rheumatoid arthritis. Researchers gave either misoprostol or a placebo to 8843 patients with rheumatoid arthritis who were also taking an NSAID. Overall, 40% fewer patients taking misoprostol had stomach or intestinal complications. Ten times as many patients taking placebo had intestinal tearing or blockage as a result of ulcers compared with the patients taking misoprostol. Risk factors for stomach and intestinal complications associated with NSAID use may include age and a prior history of ulcer or intestinal bleeding. Diarrhea was a frequent side effect in patients taking misoprostol.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1995
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Anti-inflammatory and Upper Gastrointestinal Effects of Celecoxib in Rheumatoid Arthritis:A Randomized Controlled Trial
Article Abstract:
The drug celecoxib appears to be an effective painkiller in patients with rheumatoid arthritis and is less likely than other arthritis drugs to damage the gastrointestinal tract. Celecoxib inhibits an enzyme called cyclooxygenase 2 (COX-2). Researchers randomly assigned 1,149 patients with rheumatoid arthritis to take one of several dosages of celecoxib, naproxen or a placebo, or inactive substance. Both celecoxib and naproxen caused reduced pain, but celecoxib was less likely to cause ulcers. Thirty-one percent of those who took naproxen had a gastrointestinal side effect compared to about 25% of the celecoxib users and 19% of the placebo users.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1999
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