Giant cells in arthritic synovium
Article Abstract:
Giant cells in inflamed synovial tissue from patients with different types of arthritis may be true synoviocytes and macrophages. Synovial tissue is the connective tissue membrane that lines the cavity of movable joints. A study examined the types of cells found in inflamed synovial tissue from 10 patients with osteoarthritis (OA) and 10 patients with rheumatoid arthritis (RA) and non-inflamed synovial tissue from five healthy individuals. No giant cells were found in the non-inflamed tissue from the healthy individuals. Giant cells were seen in inflamed tissue from five patients with OA and from four patients with RA. Two groups of giant cells were found in the inflamed tissue. One group of cells was similar to true synoviocytes, and the other group was similar to macrophages. Cells similar to macrophages were predominant in tissue from RA patients and cells similar to true synoviocytes were predominant in tissue from OA patients.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Is rheumatoid arthritis a failure of B cell death in synovium?
Article Abstract:
A malfunction in the balance of the production and destruction of white blood cells called B cells in joint cavity fluid may play a role in the development of rheumatoid arthritis (RA). B cells are immune cells produced and found mainly in bone marrow and possibly stimulated by other immune cells called follicular dendritic reticulum cells (FDRC). FDRC and two molecules found in joint fluid, called vascular cell adhesion molecule-1 (VCAM-1) and decay accelerating factor (DAF) are similar. Researchers have found that patients with RA have more B cells in their joint fluid as compared to normal joint fluid. VCAM-1, DAF, and an as yet undetermined molecule may together mimic FDRC and stimulate the production of B cells in joint fluid that, in turn, may stimulate an autoimmune response associated with RA.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Localisation of apoptosis and expression of apoptosis related proteins in the synovium of patients with rheumatoid arthritis
Article Abstract:
It appears that few cells in the synovial tissue of patients with rheumatoid arthritis (RA) undergo apoptosis. Apoptosis is naturally selected rather than accidental cell death. Synovial tissue samples of 11 patients with RA and five surgical patients were examined for evidence of apoptosis and levels of proteins known to initiate and inhibit cell reproduction and death. Two samples from RA patients showed minimal evidence of apoptosis. There were measurable levels of the other cell cycle proteins including Bcl-2, p53, c-myc, and p21(WAF1/CIP1) in these samples.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Associations between HLA and antibodies to collagen in rheumatoid arthritis. Shared amino acid sequences between major histocompatiblity complex class II glycoproteins, type XI collagen and Proteus mirabilis in rheumatoid arthritis
- Abstracts: Nutrition promotion and dietary change at off-shore oil installations in the Norwegian sector of the North Sea
- Abstracts: Comparison of 1% and 2.5% selenium sulfide in the treatment of tinea capitis. Asymptomatic Dermatophyte Carriers in the Households of Children With Tinea Capitis
- Abstracts: Long-term (6 months) effect of a new fermented milk product on the level of plasma lipoproteins - a placebo-controlled and double blind study
- Abstracts: Can clinical research thrive (or survive)? D.C. medical society backs single payer as a reform 'option.' (Medical Society of the District of Columbia)