Growth hormone replacement in healthy older men improves body composition but not functional ability

Article Abstract:

Treatment with growth hormone does not seem to provide any significant improvement in muscle or mental functioning in elderly men. Researchers compared the effects on muscle strength, body fat, physical coordination and endurance, mental function, and blood chemistry in 52 healthy men aged 70 to 85 years taking either insulin-like growth factor 1 or placebo. Improvements in knee muscle strength were between 1.8% and 2.5% higher in the group taking the growth hormone as compared to the group taking placebo. Participants taking growth hormone had 12.8% less fat mass, 1% higher bone mineral content, and 4.4% more lean muscle mass than participants taking placebo. There was no significant difference in physical coordination, emotional state, and hand grip strength between the two groups. Participants taking growth hormone scored 0.6 points lower on a mental functioning test than those taking placebo. Side effects caused 26% of the group taking growth hormone to take less drug.

Somatotropin, Aged men, Elderly men

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Postmenopausal Hormone Therapy Increases Risk for Venous Thromboembolic Disease

Article Abstract:

Estrogen/progestin therapy for postmenopausal women increases the risk of venous thromboembolism is woman with coronary heart disease. Of 2,763 postmenopausal women younger than 80 years, all of whom had coronary heart disease but no history of thromboembolism and had also not had hysterectomies, half were given estrogen and progesterone and half an inactive substance. The follow up averaged just over four years, and the women in the progestin/estrogen group had about three times the number of venous thromboembolisms as the other group, which amounts to an increased risk of 3.9 per 1000 woman-years.

Risk factors, Drug therapy, Thromboembolism, Postmenopausal women, Estrogen, Estrogens, Progestational hormones

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Randomized trial of medical treatment versus hysterectomy for abnormal uterine bleeding: Resource use in the Medicine or Surgery (Ms) trial

Article Abstract:

A study to compare resource use outcomes for participants in the Medicine or Surgery (Ms) randomized trials was conducted. The results revealed that for women with abnormal uterine bleeding refectory to cyclic medroxyprogesterone acetate, compared with expanded medical treatment, hysterectomy increases resource use significantly and results in better clinical and 6-month quality-of-life outcomes.

Care and treatment, Diagnosis, Women, Quality of life, Women's health, Uterine bleeding, Uterine hemorrhage

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