Gynecologic and obstetric aspects of Gaucher's disease: a survey of 53 patients

Article Abstract:

Gaucher's disease appears to increase the incidence of gynecologic and obstetric complications. Gaucher's disease is a genetically inherited metabolic abnormality most common among European Jews. It commonly causes anemia, enlarged liver and spleen, bone degeneration, and increased susceptibility to infection. Researchers analyzed the gynecologic and reproductive history of 53 women attending an Israeli clinic for Gaucher's disease. Three-fourths experienced heavy menstrual bleeding. One-fourth of 102 pregnancies ended in miscarriage in the first trimester. Low levels of blood clotting factors and anemia were common problems among the 72 pregnancies continuing past 22 weeks gestation. Thirteen percent of women having vaginal births and 56% of women having a cesarean section required a blood transfusion after delivery.

Complications and side effects

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Use of enzyme replacement therapy for Gaucher disease during pregnancy

Article Abstract:

Enzyme replacement therapy in the treatment of Gaucher disease may reduce pregnancy complications and improve the prospects of giving birth. Gaucher disease is a genetic disorder of enzyme production, and patients can develop anemia, a decreased level of blood platelets, spleen and liver enlargement, and excessive bleeding and infection. Researchers treated six patients with a history of early pregnancy loss with supplemental enzymes. Disease symptoms diminished and most of the pregnancies progressed without significant complications. Five patients delivered healthy babies.

Health aspects, Prevention, Drug therapy, Enzymes, Pregnancy, Complications of, Pregnancy complications, Enzyme therapy

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Pregnancies in Gaucher disease: A 5-year study

Article Abstract:

A study to investigate the outcome of pregnancies in Gaucher diseases, particularly in enzyme-treated women is performed on 17 treated and 26 untreated women with 66 pregnancies. Majority of the untreated women with mild disease had an uncomplicated pregnancy while the enzyme-treated women suffered from excessive bleeding and infections post partum and some had spontaneous abortions.

United States, Science & research, Labor Distribution by Employer, Research, Statistics, Pregnancy, High risk pregnancy

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