HIV-associated nephropathies

Article Abstract:

Certain kidney disorders have been associated with HIV infection. One was first diagnosed in AIDS patients in 1984. This disorder was characterized by a sudden onset of symptoms and rapid development of end-stage kidney failure. It was named HIV-associated glomerulosclerosis because it often precedes the development of AIDS. A research study evaluated two young men infected with HIV who were diagnosed with immunoglobulin A (IgA) nephropathy. IgA nephropathy is a inflammatory kidney disorder that is caused by deposition of Ig A immune complex in the kidney. Ig A is an antibody that binds to HIV as part of the body's defense against infection. Most patients with IgA nephropathy experience similar symptoms, and the disease usually progresses rather slowly. This condition has only been diagnosed in white men who are HIV-positive, but HIV-associated glomerulosclerosis mostly affects black individuals.

Editorial, HIV infection, HIV infections, Immune complex diseases

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Renal disease in children with the acquired immunodeficiency syndrome

Article Abstract:

Children infected with the human immunodeficiency virus (HIV) during the period just prior to or after birth, and develop AIDS, are at risk for renal disease. Furthermore, the incidence of renal disease (nephropathy) in pediatric AIDS patients may be similar to that which is found among adults with HIV infection. A 6.5-year study of 155 children suffering from AIDS revealed that 12 had proteinuria, protein in the urine. These 12 patients exhibited a wide range of renal (kidney) diseases, the most common being focal glomerulosclerosis, fibrous obstruction of the cluster of small capillaries in the kidney, and mesangial hyperplasia. More research is needed to define the extent of AIDS-related renal disease among children and to develop treatments for this illness.

Care and treatment, Pediatric diseases, Acute kidney failure, Glomerulonephritis, Proteinuria, AIDS (Disease) in children, Pediatric AIDS (Disease), Acute renal failure in children

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Sequential therapies for proliferate Lupus Nephritis

Article Abstract:

A study was conducted for patients infected with proliferate lupus nephritis and the effect of long term therapy with cyclophosphamide. The study concluded that for these patients, short-term therapy with intravenous cylclophosphamide followed by maintenance therapy with mycophenolate mofetil appeared to be more effective than the other therapies.

Science & research, Research, Patient outcomes, Lupus, Cyclophosphamide, Mycophenolate mofetil

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