HTLV-1 associated Sjogren's syndrom is aetiologically distinct from anti-centromere antibodies positive Sjogren's syndrome

Article Abstract:

It is likely that there are etiologically different forms of Sjogren's syndrome, one of which is characterized by HTLV-1 antibodies, another, the traditionally recognized disease which has anti-nuclear antibodies (ANA) or anti-centromere antibodies (ACA). Sjogren's syndrome is an immune disorder in which various glands become abnormally dry. In examining a test group of 135 patients with primary Sjogren's syndrome and 97 patients with secondary Sjogren's syndrome, analysis of antibodies was made and the results gave indications of the conclusion stated above, even though the manifestation of disease as symptoms were similar.

Sjogren's syndrome, Varieties, Antibodies

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Humanization of autoantigen

Article Abstract:

Genetically engineered mice model is used to show that human autoimmune disease like bullous pemphigoid (BP) can be reproduced. Humanization of autoantigens is found to be a new method for studying human autoimmune diseases.

United States, Health aspects, Models, Usage, Prevention, Causes of, Risk factors, Genetically modified mice, Bullous pemphigoid

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Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

Article Abstract:

Researchers have discovered that the B chain of insulin is the target of CD8 lymphocytes in a mouse model of diabetes. Type 1 diabetes is caused by an autoimmune attack on the pancreatic islet cells, which produce insulin.

Research, Physiological aspects, Identification and classification, Type 1 diabetes, Insulin

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