Helicobacter pylori infection of gastric mucin cell metaplasia: the duodenum revisited
Article Abstract:
Helicobacter pylori (H. pylori) infection is commonly associated with gastritis, the inflammation of the mucosa (lining) of the stomach. Clinical studies have revealed that H. pylori is also a common infection in patients with duodenal (from duodenum, the beginning part of the small intestine) ulcers. Duodenal ulcers frequently are accompanied by gastric mucin cell metaplasia (the appearance of gastric mucosa, or stomach mucous membranes, in the adjacent portion of the duodenum). Since H. pylori specifically invades the gastric mucosa, it has been suggested that H. pylori infection in the duodenum may be the underlying cause of duodenal ulcers. Treatment of H. pylori infection has been shown to increase ulcer healing and reduce the rate of ulcer recurrence. To further explore the relationship between H. pylori infection and duodenal ulcers, biopsy samples of duodenum with gastric mucin cell metaplasia were examined for the presence of H. pylori. Staining techniques were used to visualize regions of the duodenum containing gastric mucin cell metaplasia (over growth) and H. pylori infection. Gastric metaplasia was found in 88 percent of the 60 duodenal ulcer samples, and all of these samples contained H. pylori. Ninety-two percent of the regions infected with H. pylori showed signs of duodenitis (inflammation of the duodenum). It is concluded that H. pylori infection is common in gastric mucin cell metaplasia, and that this infection is related to the development of duodenal ulcers. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Journal of Pathology
Subject: Health
ISSN: 0022-3417
Year: 1990
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Reversal of Iron Deficiency Anemia after Helicobacter pylori Eradication in Patients with Asymptomatic Gastritis
Article Abstract:
Cure of Helicobacter pylori infection seems to be involved in also reversing iron dependence and bringing about recovery from iron deficiency anemia, the most common form of anemia. Investigating the effects of eradicating H. pylori with combination antibiotic therapy on iron deficiency anemia was done with 30 patients in whom the only gastrointestinal disease was H. pylori-associated gastritis. All patients had a long history of iron deficiency anemia. Therapy consisted of two antibiotics and discontinuation of iron replacement therapy. At 6 months, 75% of patients had recovered from anemia, and after 12 months, 91.7% of patients had recovered from anemia.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1999
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