Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin

Article Abstract:

Giving surgical patients low-molecular-weight heparin rather than unfractionated heparin may reduce the incidence of thrombocytopenia and its associated complications. Heparin-induced thrombocytopenia is a drop in the number of blood cells called platelets that can occur when the body produces antibodies against heparin that can activate platelets. Of 665 patients who had hip surgery, 332 were given daily injections of unfractionated heparin and 333 were given shots of low-molecular-weight heparin. Nine patients developed heparin-induced thrombocytopenia and all had received unfractionated heparin. Eight of these patients developed blood clots in major veins and arteries following heparin treatment. Blood tests done on 387 patients in the group revealed that those who received unfractionated heparin were more likely to develop antibodies against heparin.

Pulmonary embolism, Thrombosis, Deep vein, Deep vein thrombosis

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Drug-induced immune-mediated thrombocytopenia--From purpura to thrombosis

Article Abstract:

The classic symptoms of drug-induced, immune-mediated thrombocytopenia and purpura are most often caused by quinine in outpatients and by vancomycin in hospitalized patients. The quinine-induced thrombocytopenia is typically caused by unusual antibodies that bind to the drug as well as to complexes of drug bound to platelet glycoproteins.

United States, Science & research, Health aspects, Research, Disease/Disorder overview

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Temporal aspects of heparin-induced thrombocytopenia

Article Abstract:

A decrease in the blood platelet count can occur very quickly in some patients who receive heparin. In a study of 243 patients, 30% developed this adverse effect of heparin in less than 24 hours.

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