High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide sythase

Article Abstract:

High-density lipoprotein (HDL) protects against atherosclerosis by mediation of scavenger receptor-BI and by activating endothelial nitric oxide synthase in a process that requires apolipoprotein ApoA-1. This also increases nitric oxide production, which might be an important factor in the atheroprotective properties of ApoA-1 and HDL.

United States, Canada, Statistical Data Included, Cardiovascular diseases, Protein binding, Nitric oxide, High density lipoproteins

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Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure

Article Abstract:

The role of regulator of G-protein signaling-2 (RGS-2), a GTPase for Gq, as an important cGMP-dependent protein kinase-interacting-proteins (GKIPs) and substrate of cGMP-dependent protein kinase I-alpha (PKGI-alpha) is investigated. Its effect on nitric oxide (NO) action and systemic blood pressure is also studied.

Influence, Muscle contraction, Blood pressure, G proteins, Protein research, Muscle relaxation

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27-hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

Article Abstract:

Studies conducted about 27-hydroxycholesterol (27HC), a cholesterol metabolite found in atherosclerotic lesions is presented. 27HC is the major factor contributing to the loss of estrogen protection from vascular disease.

Health aspects, Estrogen, Estrogen receptors, Blood circulation disorders, Vascular diseases

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