Hodgkin's disease in patients with antibodies to human immunodeficiency virus: a study of 22 patients

Article Abstract:

The syndrome which is now referred to as AIDS was first recognized on the basis of unexplained immunosuppression, opportunistic infections, and Kaposi's sarcoma. As evidence accumulated, it became clear that the occurrence of non-Hodgkin's lymphoma, as well as some other lymphoproliferative diseases, should be included in the constellation of AIDS complications. The case of Hodgkin's lymphoma (HD, or Hodgkin's disease) is not so clear. Although some have proposed including H among the diagnostic criteria for AIDS, there is insufficient epidemiologic evidence to make this decision conclusively. Furthermore, there seem to be significant geographical differences in the incidence of Hodgkin's disease. To gather more information on this question, the cases of 22 patients with Hodgkin's disease who were also positive for the human immunodeficiency virus were reviewed. Among these patients, Hodgkin's disease showed a 50 percent incidence of bone marrow invasion, higher than in the general population. Furthermore, the patients were more likely to have advanced disease; 90 percent had Stage III or IV disease. The patients with AIDS had significantly shorter survival, but even the patients with no symptoms, or with diseased lymph nodes only, had a poorer course. Overall survival was 18 months, in contrast to the general population, where 65 percent of H patients are alive at 10 years. In this patient population, which is Spanish, the incidence of H among HIV-infected patients was roughly comparable to the general population, in contrast to the incidence in the United States, where H is less common among HIV-positive patients. (Consumer Summary produced by Reliance Medical Information, Inc.)

Complications and side effects, Demographic aspects, Diseases, HIV (Viruses), HIV, AIDS (Disease), AIDS virus carriers, HIV carriers

---

Immune deficiency in family members of patients with Hodgkin's disease

Article Abstract:

Hodgkin's disease is characterized by enlargement of lymphoid tissue, spleen, and liver, with invasion of other tissues. Previous studies have suggested that patients with Hodgkin's disease have pre-existing impairment of their immune systems. Defects in the immune system may be due to genetic or environmental factors. The immunological characteristics of 65 first-degree relatives and 12 spouses of 21 patients with Hodgkin's disease were assessed. In addition, seven sets of twins in which one twin had Hodgkin's disease, and an additional four sets of healthy twins were also studied. A decrease in the stimulated production of DNA (genetic material) of lymphocytes, a type of immune cell; an elevated spontaneous production of DNA; and a low ratio of CD4+ to CD8+ cells, which are subtypes of lymphocytes, were detected in 21 of 65 blood relatives; 2 of 12 non-blood relatives; 5 healthy twins; 14 of 21 patients with Hodgkin's disease; and 21 of 127 healthy unrelated subjects. The number of lymphocytes and lymphocyte subtypes did not differ between relatives of patients with Hodgkin's disease and healthy nonrelatives. The increased prevalence of blood lymphocyte defects among first-degree relatives suggests that deficiency of the immune system in Hodgkin's disease may be determined by genetic factors. Age and environment may also contribute to the development of immune defects. (Consumer Summary produced by Reliance Medical Information, Inc.)

Causes of, Physiological aspects, Genetic aspects

---

Similar abstracts:

• Abstracts: Mycobacterial disease in patients with human immunodeficiency virus infection. Human immunodeficiency virus-associated nephropathy
• Abstracts: Malignant plasma cell tumors in human immunodeficiency virus-infected patients. Cutaneous Hodgkin's disease in a patient with human immunodeficiency virus infection
• Abstracts: Drug abuse treatment as a strategy to prevent human immunodeficiency virus infection among intravenous drug users
• Abstracts: Gastric carcinoids and their precursor lesions: a histologic and immunohistochemical study of 23 cases. An analysis of immunocomplexes for the detection of the early stages of colon cancer
• Abstracts: Diabetic ketoacidosis and insulin resistance with subcutaneous terbutaline infusion: a case report. part 2 Randomized comparison of intravenous nitroglycerin and subcutaneous terbutaline for external cephalic version under tocolysis

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.