Cyclophosphamide versus placebo in scleroderma lung disease
Article Abstract:
A double-blind, randomized, placebo-controlled trial was conducted to determine the effects of oral cyclophosphamide on lung function and health-related symptoms in patients with evidence of active alveolitis and scleroderma-related interstitial lung disease. It was found that one year of oral cyclophosphamide in patients with symptomatic scleroderma-related interstitial lung disease had a significant but modest beneficial effect on lung function, dyspnea, thickening of the skin, and the health-related quality of life.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
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Postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever
Article Abstract:
A study examines the efficacy of a short course of the antimicrobial agent doxycycline in preventing tick-borne relapsing fever (TBRF) after high-risk activities in an area where TBRF is endemic. Results demonstrate that treatment with doxycycline is safe and efficacious in preventing TBRF after suspected exposure to ticks in a high-risk environment.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
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