Human papillomavirus types and recurrent cervical warts

Article Abstract:

The human papillomavirus (HPV) causes two physically different types of cervical intraepithelial neoplasias (CINs), which are abnormal growths or warts in the epithelial tissue lining the cervix, the opening of the uterus. There are 59 types of HPV, 22 of which have been identified in genital tract lesions. Certain types of this virus, such as HPV 16, cause the more serious cervical lesions that are associated with an increased risk for developing cancer. The standard treatments for CIN are cryotherapy (the destruction of lesions with cold treatment) or carbon dioxide laser treatment, although these treatments are associated with a five to ten percent recurrence rate of CINs within the first year. Cervical lesions recurring after cryotherapy were examined to determine if they were associated with the same type of HPV that caused the original lesion. The deoxyribonucleic acid (DNA), the genetic material of the virus, was detected in the recurrent abnormal growths of eight women, and was shown to be different from that of the original lesion. However, the same type of human papillomavirus was present in two or more CINs occurring at the same time in 11 of 12 women with multiple CINs. The results show that multiple, simultaneous CINs contain the same type of human papillomavirus, whereas recurrent CINs contain a different type of papillomavirus than that which caused the original lesion. (Consumer Summary produced by Reliance Medical Information, Inc.)

Infection, Causes of, Papillomavirus infections, Cervix uteri, Cervix diseases, Warts

---

Recurrent condylomata acuminata treated with recombinant interferon alfa-2a: a multicenter double-blind placebo-controlled clinical trial

Article Abstract:

Human papillomavirus (HPV), especially HPV types 6 and 11, often causes warts in the genital area; these warts are known as condylomata acuminata. If untreated, the lesions may lead to invasive cancer of the cervix, or more rarely, cancer of the vulva, vagina, or penis. Chemical or surgical removal of the warts is unsuccessful in preventing recurrence in up to 30 percent of cases. For this reason, and because genital infections can remain latent (present in the body without showing their effects), systemic antiviral therapy may be preferable to local treatment. Interferons have antiviral activity, and have produced regression or disappearance of some genital warts, seemingly by destroying the DNA (genetic material) of the papillomavirus. A study of the effectiveness of interferon alfa-2 on recurrent condylomata acuminata among 172 patients found that 30 percent of patients with recurring genital warts who were treated with a placebo (inactive substance) had complete or major regression of their warts by three months after treatment began. Results of treatment with two different doses of systemic interferon alfa-2 were not significantly different from the results with placebo. Therefore, interferon alfa-2 therapy was no more effective when administered according to the conventional dosage and treatment schedule than a placebo. (Consumer Summary produced by Reliance Medical Information, Inc.)

Papillomaviruses, Papillomavirus, Interferon alpha

---

New Treatments for Genital Warts Less Than Ideal Abstract and Commentary

Article Abstract:

Topical imiquimod cream and podofilox gel both appear to be effective in treating external anogenital warts, but neither treatment is optimal. Anogenital warts are caused by infection with human papillomavirus and can be sexually transmitted. Conventional treatments include freezing, destruction by trichloroacetic acid, or other procedures performed by physicians. Topical medications applied by the patients are highly desirable, but both imiquimod and podofilox take many weeks to clear the warts, and many patients do not respond or have a recurrence of warts.

Product/Service Evaluation, Topical medication, Topical drugs, Aldara (Medication)

Similar abstracts:

• Abstracts: Vitamin D supplementation and fracture incidence in elderly persons: a randomized, placebo-controlled clinical trial
• Abstracts: Vitamin D supplementation and fracture incidence in elderly persons: a randomized, placebo-controlled clinical trial. part 2
• Abstracts: A role for estriol in human labor, term and preterm. Urinary compound W in pregnant women is a potential marker for fetal thyroid function
• Abstracts: Comparison of the effects of over-the-counter famotidine and calcium carbonate antacid on postprandial gastric acid: a randomized controlled trial
• Abstracts: Quantitative synthesis in systematic reviews. Heterogeneity of the baseline risk within patient populations of clinical trials

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.