Human tissue-engineered blood vessels for adult arterial revascularization
Article Abstract:
Cardiovascular tissue engineering introduced the prospect of a completely biological, living and autologous blood vessel produced in vitro to fill the crucial need for functional small-diameter conduits. Using adult human fibroblasts extracted from skin biopsies harvested from individuals with advanced cardiovascular disease, tissue-engineered blood vessels (TEBVs) that serve as arterial bypass grafts in long-term animal models is constructed.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Engineered antibodies
Article Abstract:
In the biopharamaceuticals development, engineered antibodies form a significant part and replace the antibodies developed using hybridoma technology. The engineered antibodies facilitate designing antibody-based reagents with specificity. They can be reduced in size into antibody fragments, developed into multiple specificity molecules, and fused with radionuclides, toxins, enzymes, liposomes and viruses.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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Viral receptors and vector purification: new approaches for generating clinical-grade reagents
Article Abstract:
Vector purification and viral receptors are discussed with consideration of new approaches for generating clinical-grade reagents. Topics include immuno-affinity chromatography, using a monoclonal antibody, and heparin affinity chromatography. Purification of recombinant adeno-associated virus (AAV) vectors is discussed with consideration of the benefits of the new methods.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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