Idiopathic CD4+ T-lymphocytopenia - an analysis of five patients with unexplained opportunistic infections

Article Abstract:

The immunological activity and the disease progression characteristic of HIV infection are not seen in patients who have CD4+ lymphocytopenia without HIV infection. CD4+ T-lymphocytopenia is the depletion of certain white blood cells and is normally associated with HIV infection. Of five patients with CD4+ T-lymphocytopenia and unexplained opportunistic infections, none were infected with either HIV or human T-cell lymphotropic virus. The patients' spouses and one patient's blood donors were all healthy and had normal levels of CD4+ T-cells. Furthermore, there were no signs in these patients of any other virus-like particles that might be capable of killing CD4+ T-cells. In comparison with 100 HIV-infected patients and 30 healthy individuals, these five patients had lower counts of CD4+ cells. Immunoglobulin levels, which are usually increased in HIV patients, were normal or lower than normal in these five patients. CD4+ T-cell counts continue to drop in patients with HIV, but in these patients, levels of CD4+ T-cells changed little over time.

---

Idiopathic CD4+ T-lymphocytopenia - four patients with opportunistic infections and no evidence of HIV infection

Article Abstract:

Case studies of four patients who have CD4+ lymphocytopenia without HIV infection are discussed. CD4+ lymphocytopenia is the depletion of certain white blood cells and is seen in patients with HIV infection and in those taking immunosuppressive drugs. All four patients had severe CD4+ T-lymphocytopenia and opportunistic infections. None of the patients were infected with HIV or with human T-lymphotropic virus, and none reported any risk factors associated with HIV infection. All the patients' family members and sexual partners were healthy. Among these four patients, unlike patients with HIV infection, other white blood cells - B cells, CD8+ T-lymphocytes and natural killer cells - were also depleted. Levels of CD4+ T-cells progressively decline in HIV infection, but among these patients, the CD4+ T-cell count continued to drop in only one patient. These findings suggest that the CD4+ T-cell depletion seen in these patients and in patients with HIV infection probably stem from different mechanisms.

---

Safety and immonogenicity of an Inactivated Subvirion Influenza A (H5N1) vaccine

Article Abstract:

A multicenter, two-stage study was conducted to receive two intramuscular doses of subvirion influenza A (H5N1) vaccine. It was observed that a two-dose regimen of 90 (mu)g of this vaccine does not cause severe side effects and, in the majority of recipients, generates neutralizing antibody responses typically associated with protection against influenza, and that a conventional subvirion H5 influenza vaccine may be effective in preventing influenza A (H5N1) disease in humans.

United States, Prevention, Complications and side effects, Influenza vaccines, Influenza, Dosage and administration

Similar abstracts:

• Abstracts: Ethical implications of rejecting patients for clinical trials
• Abstracts: Major under taking: funeral workers often lack information on dealing with the bodies of people who have died from specific infections
• Abstracts: Membranoproliferative glomerulonephritis associated with hepatitis C virus infection. The danger within
• Abstracts: Practice management considerations for an aging population. Managing patients with Alzheimer's: the primary care role of dentists
• Abstracts: Schwann cells as antineuroblastoma agents. Neuroblastoma--From genetic profiles to clinical challenge. Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.