Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1: a report from the Syndney Blood Bank Cohort

Article Abstract:

Even many HIV long-term non-progressors may eventually develop immune system damage. Long-term non-progressors are people infected with HIV who remain healthy for 10 years or longer. Australian researchers have been following one HIV-infected blood donor and eight people who received blood from this donor before 1985 when blood testing for HIV began. The virus was found to be a weakened strain that had a mutation in the nef gene. Five recipients remain alive and asymptomatic 14 to 18 years after infection and are not taking any AIDS drugs. However, two have detectable virus in their blood and have steadily decreasing CD4 T cell counts.

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Naturally attenuated HIV -- lessons for AIDS vaccines and treatment

Article Abstract:

The cases of several people infected with a less aggressive form of HIV illustrates that more research is needed before these viruses are used in an AIDS vaccine. The virus has a mutation in the nef gene, which makes it much less infective. Of the eight people who became infected when they received blood from an HIV-positive donor, five survived for more than 14 years with no symptoms of HIV infection. Research showed that they were infected with an HIV strain containing the nef mutation. However, detailed examination revealed steadily decreasing CD4 T cell counts.

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Antibodies and resistance to natural HIV infection

Article Abstract:

Researchers have shown in monkeys that antibodies that neutralize HIV can protect against contracting HIV infection via mucosal surfaces. Mucosal surfaces are most likely to become infected when the virus is transmitted sexually or orally.

Prevention

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