Implications of halted study's finding's for hypertension guidelines unclear

Article Abstract:

The data from Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) which was halted in December 2004 at the recommendation of the trial's independent data safety monitoring board when an interim analysis of the data found that a newer treatment strategy of amlodipine and perindopril was superior to the older treatment regimen of atenlol and bendroflumethiazide. Experts are divided over whether findings from the ASCOT trial warrant changes in treatment guidelines for high blood pressure.

Science & research, Research, Hypertension, Diagnosis, Risk factors, Drug therapy, Dosage and administration, Amlodipine

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Drug safety reform at the FDA - Pendulum swing or systematic improvement?

Article Abstract:

Legislation for major drug safety reform at the U.S. Food and Drug Administration (FDA) for protection against drug' risk, based on recommendations by Institute of Medicine (IOM) is expected to be passed in 2007. The proposed drug safety reforms include increased funding for FDA and postmarketing surveillance of drugs

Product development, Legal issues & crime, Government regulation (cont), Government domestic functions, Government regulation, Management dynamics, Pharmaceutical preparations, Legal/Government Regulation, Management, Interpretation and construction, Laws, regulations and rules, Pharmaceutical industry, Company business management, United States. Food and Drug Administration, Drug approval, Health policy, Pharmaceutical laws

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