Independent divergences in the CD4 binding site and V3 loop encoded in two seroprevalent Ugandan HIV-1 clinical isolates
Article Abstract:
UG06c and UG23c are two distinct African subgroups of HIV type 1 (HIV-1). The subgroups have antigens on their surface that are recognized by antibodies from HIV-infected individuals from Africa and North America. A genetic analysis was done of the V3 loop of the gp120 protein and the CD4 T cell recognition site of UG06c and UG23c from African AIDS patients. The V3 loop of gp120 and the CD4 T cell recognition site are two types of antigens on the surface of HIV-1. UG06c and UG23c are both distinct subtypes of HIV-1 with specific types of antigens on their surface. Both subtypes reacted with antibodies in the blood of African and North American individuals with asymptomatic HIV infection.
Publication Name: Journal of Acquired Immune Deficiency Syndromes
Subject: Health
ISSN: 0894-9255
Year: 1993
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Helper T-cell recognition of HIV-1 Tat synthetic peptides
Article Abstract:
Tat protein may activate helper CD4+ cells in individuals infected with HIV type 1 (HIV-1). This protein is a regulatory protein that is necessary for replication of HIV-1. A study examined response of helper CD4+ T cells to recombinant (genetically engineered) Tat protein and 12 different Tat protein subunits in 15 HIV-positive individuals and 11 HIV-negative individuals (control group). HIV-positive individuals were more likely to have a response to recombinant Tat than those in the control group. Three Tat protein subunits caused a helper CD4+ T cell response in the HIV-positive individuals but not in HIV-negative individuals.
Publication Name: Journal of Acquired Immune Deficiency Syndromes
Subject: Health
ISSN: 0894-9255
Year: 1993
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Interleukin-10 gene expression induced by HIV-1 Tat and Rev in the cells of HIV-1 infected individuals
Article Abstract:
The production of interleukin-10 in HIV-infected patients could explain the immunosuppression these patients experience. Researchers took blood samples from 8 HIV-infected patients and exposed the samples to proteins from HIV. All but one of the samples produced interleukin-10 upon viral stimulation. This indicates that the T lymphocyte helper type-2 cells were being stimulated. The production of interleukin-10 could cause the defect in cell-mediated immunity, since interleukin-10 is known to suppress the immune system.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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