Insulin-dependent diabetes mellitus associated with danazol

Article Abstract:

Endometriosis develops when cells normally lining the inside of the uterus dislodge, travel and begin growing elsewhere, such as in the fallopian tubes, ovaries or abdominal cavity. The cells respond to hormones produced in the ovaries as if they were still inside the uterus. Pain is a common symptom during menstruation and sex, but can also occur during defecation. The condition is often a cause of infertility. Diagnosis is confirmed by examining pelvic structures by laparoscopy, a procedure in which a tube affixed with a microscope is inserted through a small opening in the abdomen to visualize internal structures. Danazol, a synthetic androgen (a male hormone) that suppresses the release of hormones of the ovaries, is used to control the symptoms of endometriosis. A 26-year-old woman with a six-month history of infertility and painful periods since age 20 was diagnosed with endometriosis by laparoscopic evaluation. Danazol (400 mg twice a day) treatments were initiated. The symptoms of endometriosis improved over the next two months, at which point symptoms of diabetes developed, namely increased thirst and urination, hunger, nausea, fatigue, weight loss and blurry vision. High blood sugar, indicative of diabetes mellitus after diagnostic tests were performed. Danazol treatments were discontinued and insulin and diet therapy was started. A month later the insulin and diet therapy was discontinued on a trial basis with resolution of diabetes. Five months later mild hyperglycemia (high blood sugar) developed. Although danazol is thought to alter carbohydrate metabolism, this is the first report of danazol-induced diabetes mellitus. It is suspected that this patient had a predisposition for diabetes mellitus which was potentiated by danazol therapy. (Consumer Summary produced by Reliance Medical Information, Inc.)

Causes of, Complications and side effects, Development and progression, Drug therapy, Diabetes, Diabetes mellitus, Endometriosis, Infertility, Female, Female infertility, Danazol

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Blood exposure in single versus double gloving during pelvic surgery

Article Abstract:

There is growing concern over the adequacy of surgical gloves as a barrier to infections. There have been many studies examining the quality of brand name and generic surgical gloves, but not the rate of infection transmission between patients and surgeons. Many surgeons now wear two pairs of surgical gloves to protect them from blood infected with the human immunodeficiency virus (HIV). The presence of patient's blood on the hand of surgeons using single or double surgical gloves was ascertained after 45 obstetrical or gynecological operations. Single gloves were worn by 42 surgeons and double gloves were worn by 48 surgeons. Visible blood was found on the hands of 16 single-gloved surgeons (38 percent) and one double-gloved surgeon (2 percent). The presence of blood on the hand of the surgeon was not related to the type of operation or the expertise of the surgeon. Therefore, it is likely that any particle the size of a red blood cell can pass through the single glove barrier. The use of double gloves resulted in fewer reported cases of visible blood during surgical operations. It is suggested that a single glove worn during surgery is not an effective barrier to infection. (Consumer Summary produced by Reliance Medical Information, Inc.)

Usage, Evaluation, Diseases, Surgery, Disease transmission, Blood, Contamination, Materials, Rubber gloves, Gloves (Surgery)

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Immunocytochemical evidence for the presence and location of the neurotrophin-Trk receptor family in adult human preovulatory ovarian follicles

Article Abstract:

Presence and absence of neurotrophins and their respective receptors within adult human preovulatory follicles are studied. Conclusion is provided that neurotrophins and their respective receptor proteins are present within the mural and cumulus granulosa cells of adult human preovulatory follicles.

Science & research, Research, Immunocytochemistry, Neurotrophins, Granulosa cell tumor, Neurotropin, Granulosa cell tumour

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