Interruption of highly active antiretroviral therapy in HIV clinical practice
Article Abstract:
The frequency of a first therapy interruption (TI) (more than or equal to) 12 weeks is investigated, to identify factors associated with TI and with therapy resumption, and the risk of developing clinical events during TI and during continuous therapy is compared. TI occurring in clinical practice is associated with an increased risk of clinical progression, and hence it should be discouraged outside strictly experimental settings.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2005
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Switching to a protease inhibitor-containing, nucleoside-sparing regimen (lopinavir/ritonavir plus efavirenz) increases limb fat but raises serum lipid levels
Article Abstract:
The effects of nucleoside-sparing and protease inhibitors sparing regimens on fat distribution, bone mineral density and metabolic parameters are evaluated in 62 subjects. Results provide additional evidence that nucleoside analogues are important in the progressive limb fat loss that characterizes antiretroviral treatment and that switching medications can significantly improve this complication.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2007
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Outcome of a second-line protease inhibitor-containing regimen in patients failing or intolerant of a first highly active antiretroviral therapy
Article Abstract:
HIV patients who do not respond to one protease inhibitor may not respond to others either, according to a study of 263 patients. Any further therapy should be guided by the results of drug susceptibility tests on the virus and the side effects of protease inhibitors.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2000
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