Papillomavirus detection: demographic and behavioral characteristics influencing the identification of cervical disease

Article Abstract:

Women with cervical human papillomavirus (HPV) infections who have only mild changes on a Pap smear probably do not have cervical cancer or its precursor, a condition called cervical intraepithelial neoplasia (CIN). In a study of 1,007 women, those with mild changes were less likely to be infected with HPV types that have been linked to cervical cancer. Women with CIN were more likely to have these viral types.

Health aspects

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Relevance of human papillomavirus screening in management of cervical intraepithelial neoplasia

Article Abstract:

A new commercially available test kit for human papillomavirus (HPV) may not be sufficiently sensitive to determine the severity of HPV in abnormal Pap smears. Researchers tested the diagnostic ability of the HPV Profile kit, approved by the Food and Drug Administration to be used in making treatment decisions for patients with abnormal Pap smears. More than 40% of women with cervical cancer of grades 2 or 3 were not diagnosed with the HPV Profile kit. Such women would not have received more extensive testing or been biopsied if kit results alone had been used.

Evaluation, Product/Service Evaluation, Medical testing products, Diagnostic reagents and test kits, Diagnostic reagents, HPV Profile (Medical test kit)

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Is human papillomavirus testing an effective triage method for detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia?

Article Abstract:

The polymerase chain reaction appears to be effective in detecting human papillomavirus type 16 in cervical tissue samples from women with an abnormal Pap smear. Researchers used this screening method on 1,007 women with an abnormal Pap smear. A total of 553 had high-grade cervical intraepithelial neoplasia, which is a risk factor for cervical cancer. Human papillomavirus type 16, which is also a risk factor for cervical cancer, was found in 60% of these women, but only in 33% of the women without cervical intraepithelial neoplasia.

Testing, Papillomaviruses, Papillomavirus, Polymerase chain reaction

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