Lamivudine-Zidovudine Combination for Prevention of Maternal-Infant Transmission of HIV-1
Article Abstract:
The AIDS drug combination zidovudine-lamivudine can substantially reduce the risk of HIV transmission from a pregnant woman to her child but the treatment has substantial side effects and the virus can become resistant. This was the conclusion of a study of 455 HIV-infected pregnant women who received the drug combination and 899 who had received zidovudine alone.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
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Perinatal HIV-1 Transmission, Part 1
Article Abstract:
Zidovudine and elective cesarean delivery may significantly reduce the risk of HIV transmission during childbirth by HIV-infected women. Researchers studied factors influencing HIV transmission among 2,834 infants and their HIV-positive mothers. Zidovudine antiviral medication was used by 902 women to reduce the risk of HIV transmission. HIV was transmitted to infants by 17% of women not taking zidovudine and 6% of treated women. Cesarean delivery was not protective when zidovudine was not used, but the rate of HIV transmission was lower in drug-treated women delivered by cesarean.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
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Perinatal HIV-1 Transmission, Part 2
Article Abstract:
Zidovudine and elective cesarean delivery may significantly reduce the risk of HIV transmission during childbirth by HIV-infected women. Researchers studied factors influencing HIV transmission among 2,834 infants and their HIV-positive mothers. Zidovudine antiviral medication was used by 902 women to reduce the risk of HIV transmission. HIV was transmitted to infants by 17% of women not taking zidovudine and 6% of treated women. Cesarean delivery was not protective when zidovudine was not used, but the rate of HIV transmission was lower in drug-treated women delivered by cesarean.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
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