Lentiviral-mediated silencing of SOD1 through RNA interferences retards disease onset and progression in a mouse model of ALS
Article Abstract:
The study report that in superoxide dismutase (SOD1) transgenic mice, a model for familial amyotrophic lateral sclerosis (ALS), intraspinal injection of a lentiviral vector that produces RNAi-mediated silencing of SOD1 substantially retards both the onset and the progression rate of the disease. Lentiviral-mediated silencing of a mutated gene may equally be applicable to other neurodegenerative disorders related to a toxic gain-of-function.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
Article Abstract:
Three different mouse models with different forms of the rhinovirus-induced disease are employed to study the exacerbation of allergic airway inflammation and asthma in humans. The study has been found to be extremely helpful in the development of therapies for the treatment of cold and asthma exacerbations.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2008
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A transgenic mouse model for monitoring endoplasmic reticulum stress
Article Abstract:
Endoplasmic reticulum (ER) stress is caused by the accumulation of unfolded proteins in the ER lumen and is connected with vascular and neurodegenerative diseases. The stress indicator was constructed by fusing XBP-1 and venus , a variant of green fluorescent protein.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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