Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide
Article Abstract:
The research has shown that [Cu.sup.2+] triggers hepatocyte apoptosis through activation of acid sphingomyelinase (Asm) and release of ceramide. The individuals with Wilson disease have showed increased plasma levels of Asm and have displayed a constitutive increase of ceramide- and phosphatidylserine-positive erythrocytes, suggesting a previously unidentified mechanism for liver cirrhosis and anemia in Wilson disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Newly expressed SUR1-regulated NC(sub Ca-ATP) channel mediates cerebral edema after ischemic stroke
Article Abstract:
A study evaluating the involvement of a nonselective cation channel, the NC(sub Ca-ATP) channel, in ischemic astrocytes that are regulated by sulfonylurea receptor 1 (SUR1) in rodent models of stroke was conducted. The results indicated that the NC(sub Ca-ATP) channel is crucially involved in development of cerebral edema, and that targeting SUR1 might provide a new therapeutic approach to stroke.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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