Long-term risk of colorectal cancer after excision of rectosigmoid adenomas
Article Abstract:
Patients who have benign colorectal tumors surgically removed have a low risk of subsequently developing cancer if a single, small tumor was removed. Those who have several tumors or a larger tumor have a higher risk and should have regular colonoscopic examinations. Of 1,618 patients who had colorectal tumors removed, 842 patients had tubulovillous, villous or large tumors and 776 had small tubular (singular or multiple) tumors. Forty-nine patients developed colorectal cancer an average of 13 years after surgery; 35 developed colon cancer and 14 rectal cancer. Thirty-one patients with tubulovillous, villous or large tumors developed colon cancer, but only four patients with small tubular tumors developed colon cancer. Of the 14 who developed rectal cancer, 12 had large or tubulovillous tumors. Eleven of the patients who developed rectal cancer had tumors that were not completely removed, and did not have frequent follow-up examinations.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1992
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Cushing's syndrome caused by corticotropin secretion by pulmonary tumorlets
Article Abstract:
A case is reported of a 19-year-old girl whose symptoms of Cushing's syndrome were traced to pulmonary tumorlets. Pulmonary tumorlets are small neuroendocrine cells in the lungs that resemble cancer. The girl was diagnosed with Cushing's syndrome at the age of 9, when she was found to have elevated blood levels of cortisol. Her blood levels of ACTH were also elevated but the source of excess ACTH could not be found. Her adrenals were removed and she recovered. At 19 years, her ACTH levels were still elevated and a CT of her lungs revealed hundreds of tumorlets in her right lower lobe. When it was removed, her symptoms resolved.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
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Prophylactic surgery to reduce the risk of gynecologic cancers in the Lynch syndrome
Article Abstract:
A study aims to determine the reduction in the risk of gynecologic cancers associated with prophylactic hysterectomy and bilateral salpingo-oophorectomy in women with Lynch syndrome. The findings suggest that prophylactic hysterectomy with bilateral salpingo-oophorectomy is an effective strategy for preventing endometrial and ovarian cancer in women with Lynch syndrome.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
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- Abstracts: A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa. Repair processes in the treatment and induction of cancer with radiation
- Abstracts: Cervical disk disease. Pancreatic enhancement after low-dose infusion of Mn-DPDP. The pituitary "incidentaloma"
- Abstracts: Vulnerability of the brain and heart after cardiac arrest. Amaurosis fugax. A randomized clinical study of a calcium-entry blocker (lidoflazine) in the treatment of comatose survivors of cardiac arrest
- Abstracts: Meconium for drug testing. Effects of maternal hypertension in very-low-birth-weight infants. Attitudes about sibling visitation in the neonatal intensive care unit
- Abstracts: Estrogen improves psychological function in asymptomatic postmenopausal women. Some misconceptions concerning the menopause