Differential Th1/Th2 cytokine patterns in chronic arthritis: interferon gamma is highly expressed in synovium of rheumatoid arthritis compared with seronegative spondyloarthropathies
Article Abstract:
Th1 expression is greater than Th2 expression in the joints of patients with rheumatoid arthritis. This confirms that Th1 expression is inflammatory, whereas Th2 expression is anti-inflammatory.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 2000
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Detection of cytokine producing cells in the synovial membrane from patients with rheumatoid arthritis
Article Abstract:
An immunohistochemical method can efficiently stain biopsied synovial tissue for the location specific cytokine-producing cells. Cytokines are chemicals in the body involved in inflammation. Synovial tissue is the material lining the joints. Researchers obtained synovial biopsy tissues from nine patients with rheumatoid arthritis. The tissues were frozen and prepared as slides. The slides were stained for two-color immunohistologic analysis with sequentially applied cytokine antibodies for 19 different antibodies. Microscopic examination showed labelled cytokines clearly visible, mainly in the Golgi bodies of producer cells. Between patients there was a great deal variation in patterns of cytokine production. Cytokines from T cells were predominant in tissues from patients with active inflammation.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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Loss of laminin and of the laminin receptor integrin subunit alpha 6 in situ correlates with cytokine induced down regulation of alpha 6 on fibroblast-like synoviocytes from rheumatoid arthritis
Article Abstract:
The inflammatory changes of arthritis may be associated with altered expression of matrix proteins in the joint. Researchers compared synovial membrane samples from arthritic and healthy volunteers, and determined that the loss of laminin and the reduced expression of the alpha 6 integrin subunit was common in rheumatoid arthritis. The presence of laminin and alpha 6 subunits was balanced and similar in osteoarthritic and normal synovial samples. Proinflammatory processes in the joint may contribute to these changes.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1998
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