Lowering cholesterol with drugs and diet
Article Abstract:
Reducing cholesterol levels is clearly beneficial and, on a public health scale, should involve diet therapy, not just drug therapy. A 1995 study found that pravastatin safely reduced cholesterol levels in men with high cholesterol levels but without coronary heart disease. Furthermore, these men experienced a 33% reduction in risk of death from coronary artery disease without increased mortality from other causes. Lowering cholesterol levels inhibits the narrowing of arteries with plaques, which can lead to strokes and heart attacks. However, blood cholesterol levels may not be the most useful indicator in prescribing therapy for lowering cholesterol. Another 1995 study showed that consuming margarine containing sitostanol ester reduced low-density lipoprotein levels in men with somewhat high cholesterol levels. These men had a large dietary intake of cholesterol, thus the study does not indicate if this margarine would benefit people on low-cholesterol diets.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1995
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Antioxidant vitamins and coronary heart disease
Article Abstract:
Antioxidant vitamins may prevent coronary heart disease. Two large-scale research studies found that large doses of vitamin E may reduce the risk of coronary heart disease in both women and men. People who take high doses of vitamin E may also exercise more and take aspirin. Aspirin may also prevent coronary heart disease. The oxidation of lipoproteins may play an important role in the development of atherosclerosis. Low-density lipoprotein (LDL) that has been oxidized may have more potential to cause atherosclerosis than unoxidized LDL. Oxidized LDL attracts cells of the immune system, which are converted to cholesterol-containing foam cells. These cells form the fatty streaks found in early atherosclerotic lesions. Different substances that lower blood levels of LDL may also help prevent atherosclerosis.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1993
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Cardiac rehabilitation and secondary prevention of coronary heart disease
Article Abstract:
All patients with symptomatic coronary artery disease should meet with their doctor to develop a comprehensive rehabilitation program that focuses on preventing future heart attacks. Patients with heart failure and those who have received a heart transplant should also participate in a rehabilitation program.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
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