Decreased fetal erythropoiesis and hemolysis in Kell hemolytic anemia
Article Abstract:
Fetuses with Kell anemia may have fewer young red blood cells and lower bilirubin levels than fetuses with RhD anemia. Treatment of Kell anemia may be improved by using fetal blood sampling rather than amniotic fluid sampling to determine the degree of anemia. Researchers compared the processes of red blood cell creation and destruction in anti-Kell and anti-D anemia in 93 pregnancies. Positive antigens were identified in 65 of the fetuses, with 54 anti-D and 11 anti-Kell antigens. Anti-Kell anemic fetuses had lower counts of young red blood cells, less than 30%, before transfusion and lower bilirubin levels than did RhD anemic fetuses. Anemia caused by destruction of red blood cells, such as in Kell anemia, may be caused by enhanced destruction of young red blood cells that do not have enough hemoglobin.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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Effect of intravenous beta-sympathomimetic tocolysis on human fetal serum erythropoietin levels
Article Abstract:
Treatment with intravenous tocolytic drugs may increase fetal blood levels of erythropoietin, a hormone produced in response to reduced blood levels of oxygen. Tocolytic drugs are used to inhibit uterine contractions in preterm labor. Among 27 pregnant women who were treated intravenously with beta-sympathomimetic drugs, 16 stopped treatment less than 24 hours before delivery and 11 stopped treatment 24 hours or more before delivery. Blood levels of erythropoietin were significantly higher in the fetuses whose mothers stopped treatment less than 24 hours before delivery compared to those who stopped treatment more than 24 hours before delivery. No difference was found between the two groups in regards to gestational age, birth weight, method of delivery and presence or duration of labor.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1993
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