Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
Article Abstract:
A model of [beta]-cell carcinoma was used to show that recruitment and activation of mast cells is required for both angiogenesis and macroscopic expansion of Myc-dependent islet tumors. The findings suggest that inhibitors of mast cell function might turn out therapeutically useful in restraining expansion and survival of pancreatic and other cancers.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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R-Ras is a global regulator of vascular regeneration that suppress intimal hyperplasia and tumor angiogenesis
Article Abstract:
R-Ras-null mice was used to explore the invivo function of this small GTPase belonging to the Ras family that regulates cell survival and integrin activity. The findings reveal the role of R-Ras as a regulator of vascular differentiation that primarily affects the remodeling of blood vessels.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Imaging of angiogenesis: from microscope to clinic
Article Abstract:
Imaging technologies have a central role in understanding the mechanisms and functional implications of angionesis. Advances in imaging have transformed angiogenesis and the evaluation of drugs that stimulate or inhibit angiogenesis in preclinical models and human disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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