Medical management of glaucoma

Article Abstract:

Many different classes of drugs are available to treat glaucoma. Glaucoma occurs when damage to the optic nerve causes loss of vision and ultimately blindness. One of the risk factors is increased pressure inside the eye. This is usually caused by an increase in fluid inside the eye or a decrease in fluid removal. Beta blockers such as timolol are effective in reducing fluid production. Prostaglandins, drugs that inhibit carbonic anhydrase and drugs that mimic acetylcholine are also effective in lowering pressure. The active chemical in marijuana is also known to lower pressure in the eye.

Drug therapy

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Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A)

Article Abstract:

Researchers have identified 16 genetic mutations that are likely related to the development of glaucoma, an eye disorder that damages the optic nerve and may cause blindness. Genetic testing of the GLC1A gene was conducted on 716 patients with open-angle glaucoma and 596 healthy volunteers. Mutations in the gene were detected in 4.6% of glaucoma patients, and fewer than 1% of healthy patients. If these mutations can be linked to clinical features of glaucoma, genetic testing could be used to identify people at risk for the condition before it develops and threatens their vision.

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The search for glaucoma genes - implications for pathogenesis and disease detection

Article Abstract:

Research linking glaucoma with certain genetic mutations is only the first step toward improving early diagnosis of this condition. Glaucoma is a progressive eye disorder, often including elevated pressure in the eye, that can cause blindness. It typically causes no symptoms, and is more prevalent in older people. Identification of a group of genetic mutations that are associated with high intraocular pressure and earlier onset of glaucoma is an important development. Nevertheless, these mutations are only found in a small number of patients with glaucoma.

Editorial

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