Mifepristone (RU 486) compared with high-dose estrogen and progestogen for emergency postcoital contraception
Article Abstract:
Mifepristone (RU 486) may be more effective than the standard combination of estrogen and progestogen for emergency postcoital contraception. Postcoital contraception terminates an unwanted pregnancy within 72 hours of unprotected intercourse or contraception failure. Among 800 women and adolescents who requested postcoital contraception within 72 hours of unprotected intercourse, 402 were treated with 600 milligrams (mg) of mifepristone and 398 were treated with 100 micrograms of estradiol and one mg of norgestrel two times 12 hours apart. Four women treated with estradiol and norgestrel became pregnant, compared with none of the women treated with mifepristone. Fewer women treated with mifepristone suffered from nausea or vomiting, compared with those treated with estradiol and norgestrel. Mifepristone is a synthetic steroid that prevents implantation of the fertilized egg in the uterus.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1992
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Emergency postcoital contraception
Article Abstract:
There are many contraceptives that can also be used as emergency postcoital contraceptives. As such, they can be used to prevent pregnancy in a woman up to 72 hours after unprotected intercourse. The common birth control pill can prevent 75% to 80% of pregnancies in these cases. High-dose estrogen, mifepristone and the copper intrauterine device are also highly effective. Many pharmaceutical companies and governments are reluctant to publicize this information because of the anti-abortion movement. However, any drug that prevents ovulation or implantation of the embryo is not considered an abortion drug.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1997
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The effects of self-administering emergency contraception
Article Abstract:
Making emergency contraception available over-the-counter may help reduce the number of unwanted pregnancies. This type of contraception must be used within 72 hours of intercourse. Researchers gave 549 women a supply of emergency contraceptive pills and an additional 522 women were told to see a physician for the pills. Almost half of the women who received a home supply of pills took them at least once, compared to 27% of the other women. Eighteen unplanned pregnancies occurred in women with a home supply compared to 25 in other group.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
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