Multiple myeloma in pregnancy: a case report

Article Abstract:

Multiple myeloma is a type of cancer composed of bone marrow blood cells that tends to destroy bone tissue. Symptoms include bone fractures, neurological deficits from tumor compression, and frequent bacterial infections. Bone pain is the most common initial symptom. Low blood calcium, anemia and kidney failure can be present during advanced disease. Multiple myeloma during pregnancy is rare. A 33-year-old woman in her 20th week of pregnancy complained of dizziness and was found to be anemic. Blood and urine protein analysis detected two component proteins commonly found in patients with multiple myeloma. Bone marrow biopsy confirmed the diagnosis. Since the patient was not experiencing symptoms and was early in her pregnancy, chemotherapy was not used. At 26 weeks of pregnancy the patient experienced fainting spells and blood cells were transfused. The level of M-protein remained unchanged, but abnormal glucose tolerance developed and diabetes was diagnosed. A normal healthy infant was delivered at 38 weeks of pregnancy. The patient received chemotherapy following delivery. Although kidney complications and diabetes continued, the condition of the mother remained unchanged. A small amount of the mother's proteins were detected in the infant's blood and amniotic fluid initially. The immunoglobulin G protein levels resolved three months later and the infant remains unaffected. (Consumer Summary produced by Reliance Medical Information, Inc.)

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Multiple myeloma in pregnancy: a case report

Article Abstract:

Multiple myeloma is a type of cancer composed of bone marrow blood cells that tend to destroy bone tissue. Symptoms include bone fractures, neurological deficits from tumor compression, and frequent bacterial infections. Bone pain is the most common initial symptom. Low blood calcium, anemia and kidney failure can be present during advanced disease. Multiple myeloma during pregnancy is rare. A 32-year-old pregnant women complained of right shoulder pain, numbness, dizziness, difficulty breathing and blurred vision. One week later, a normal healthy infant was delivered. Three days after delivery she returned to the hospital with continued numbness, particularly on the right side, back pain, heavy vaginal bleeding and frequent urination. Neurological testing detected lower leg weakness and decreased sensitivity to pinprick tests. Bone marrow biopsy revealed multiple myeloma; chemotherapy and radiation therapy were given. The patient remains alive eight months after initial diagnosis, but the prognosis of women with multiple myeloma is poor. The children of the five reported cases during pregnancy do not appear to be affected. (Consumer Summary produced by Reliance Medical Information, Inc.)

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Cis-platinum combination chemotherapy during pregnancy for advanced ovarian carcinoma

Article Abstract:

Epithelial carcinoma is responsible for 90 percent of all ovarian cancers. Ovarian cancer rarely occurs during pregnancy. A 28-year-old woman in her 16th week of pregnancy complained of severe abdominal pain. Emergency surgery revealed a large amount of fluid in her abdomen and a large mass in her left ovary. The ovary was removed and epithelial cell carcinoma of the ovary was diagnosed. Although chemotherapy can potentially affect the growth of the fetus, cis-platinum-based combination chemotherapy was given throughout the remainder of the pregnancy. Fetal growth remained normal during the remainder of the pregnancy, and a normal healthy infant was born at term. One month later a second exploratory surgery was performed to see if the disease had returned. All washings and biopsies were negative. The infant and mother have no evidence of disease 19 months later. Since the adverse effects of chemotherapy given during pregnancy are not known, the infant continues to be evaluated for any neurodevelopmental abnormalities. (Consumer Summary produced by Reliance Medical Information, Inc.)

Complications and side effects, Ovarian cancer, Chemotherapy, Cisplatin

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