N-Terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease
Article Abstract:
Study is presented to determine the relationship between N-Terminal pro-brain natriuretic peptide (NT-proBNP) levels and severity of pulmonary hypertension and prospective mortality in patients with sickle cell disease (SCD). Results suggest that a high NT-proBNP level is associated with pulmonary hypertension and is a major risk factor for patients dying of SCD.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2006
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Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease
Article Abstract:
A study is conducted to explore the role of arginase in sickle cell disease pathogenesis, pulmonary hypertension, and mortality. It is concluded that the data support a novel mechanism of disease in which hemolysis contributes to reduced nitric oxide bioavailability and endothelial dysfunction via release of erythrocyte arginase.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2005
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