Neonatal complications in newborns with an umbilical artery pH less than 7.00

Article Abstract:

Newborns who have an umbilical cord blood pH level of 7.00 or less may experience multiorgan complications. Low blood pH may indicate the newborn did not receive enough oxygen during labor and delivery. Researchers identified 84 newborns without developmental defects whose cord blood pH measured less than 7.00, and compared their outcomes to those of 84 newborns whose cord blood pH was over 7.24. Newborns with low blood pH levels were more likely to be resuscitated and intubated, and to have respiratory, gastrointestinal, cardiovascular, and neurologic complications than were newborns with pH levels over 7.24.

Analysis, Measurement, Infants (Newborn), Newborn infants, Fetal blood, Multiple organ failure, Hydrogen-ion concentration, pH measurement

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Proton magnetic resonance spectroscopy of fetal lamb brain during hypoxia

Article Abstract:

Proton magnetic resonance spectroscopy can be used to detect lactate in the brain. Lactate is produced during the breakdown of blood sugar in the absence of oxygen. Thus it can be a sign of hypoxia, or low blood oxygen levels. Researchers used proton magnetic resonance spectroscopy to measure various chemicals in the brains of fetal lambs while they were receiving adequate oxygen and again while they were deprived of oxygen. The presence of lactate was clearly visible during hypoxia but not during periods of adequate oxygen delivery.

Usage, Brain, Hypoxia, Anoxia, Magnetic resonance imaging

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A common mutation in the 5,10-methylenetetrahydrofolate reductase gene as a new risk factor for placental vasculopathy

Article Abstract:

A substitution of thymine for cytosine at position 677 in the gene for 5,10-methylenetetrahydrofolate reductase appears to increase the risk of placental abnormalities. Twelve percent of 165 women with placental abnormalities had the mutation compared to 5% of 139 women with no placental abnormality.

Abnormalities, Gene mutations, Gene mutation, Genetic aspects, Placenta, Abruptio placentae, Placental abruption

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