New treatments for Chlamydia trachomatis

Article Abstract:

Chlamydia trachomatis is the most common sexually transmitted bacteria. Infection with C. trachomatis can cause inflammation of the genital tract and urethra, and is also reported to be associated with ectopic pregnancy (development of the fetus outside of the uterus), premature birth, and infertility. The infection can be transmitted from mother to infant at the time of birth, causing eye and lung infections in the newborn infant. The most effective drugs for treating chlamydial infections are tetracycline, doxycycline, erythromycin, clindamycin, amoxicillin, and azithromycin. The standard treatment for infections with C. trachomatis is oral tetracycline (500 milligrams, four times a day for seven days) or oral doxycycline (100 milligrams, two times a day for seven days). It is possible for chlamydial infections to reappear after they have been treated. In a study that included 176 women with chlamydial infections, 40 percent developed recurrent infections within two years after drug treatment. Treatment of chlamydial infections during pregnancy is difficult. Tetracycline cannot be used during pregnancy and erythromycin has been reported to cause gastrointestinal problems. However, amoxicillin has been shown to be effective in treating pregnant women with chlamydial infections. One of the problems associated with treating chlamydial infections is that the antibiotics have to be taken several times a day for seven days. When patient compliance is poor, the chance of reinfection increases. Azithromycin is a newer drug that can eliminate chlamydial infections after a single oral dose of 500 milligrams, which provides an advantage over other treatments. (Consumer Summary produced by Reliance Medical Information, Inc.)

Drug therapy, Chlamydia trachomatis

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Is tubal ligation a risk factor for low bone density and increased risk of fracture?

Article Abstract:

Having had a tubal ligation does not appear to increase the risk of bone fractures due to osteoporosis among elderly women. Some reports have found that tubal ligation can cause estrogen deficiency, and estrogen deficiency can lead to loss of bone mass. Study participants consisted of 2215 white women aged 65 or older who are being followed in the Study of Osteoporotic Fractures. Eighty-nine women reported in response to a questionnaire that they had undergone a tubal ligation. They were compared with the remainder of the group. Women who had undergone tubal ligation tended to have lower bone density than women who had not. However, women were equally likely to have experienced a hip fracture or an osteoporotic fracture in both groups. Therefore, the reduction in bone density, if valid, was clinically unimportant.

Risk factors, Osteoporosis

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Chlamydia trachomatis and febrile complications of postpartum tubal ligation

Article Abstract:

Women infected with chlamydia at the time of postpartum tubal ligation may be prone to develop postoperative complications including fever. Chlamydia trachomatis is the most common sexually transmitted organism in the US. Researchers analyzed records of 1,447 women who were tested for chlamydia within two weeks of delivery and who underwent postpartum tubal ligation. Women who were infected with chlamydia at delivery were more likely to have postoperative complications including fever. Sensitive and quick chlamydia diagnostic tests and prompt treatment may prevent complications following postpartum surgery as well as reduce hospital costs and hospital stays.

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