Nutritional factors associated with benign breast disease etiology: a case-control study

Article Abstract:

Breast cancer appears to develop in stages; the first may be benign breast disease (BBD), which can precede malignant (cancerous) tumors by several years. Researchers are attempting to identify factors that could prevent the transformation from benign to malignant tumor. Dietary fat is being investigated; animal studies have shown that a high-fat diet enhances mammary (breast) tumor growth. Results of human studies have been inconclusive. This study surveyed large numbers of women in Israel concerning their usual diet. Included were 854 women with BBD, 755 women without BBD but who had been hospitalized for minor surgery, and 723 women who had neither BBD nor other surgery but lived near to the BBD subjects. This last group shared the general environment of the BBD patients. Results of the survey showed that women with advanced BBD (grade 3 or higher) ate more high-fat foods, particularly foods high in saturated fat, than the two control groups. Saturated fat is typically found in foods of animal origin such as meat and dairy products. The authors conclude that these results support the theory that a high-fat diet increases the risk of developing breast cancer. It should be noted that the method of evaluating the diet was less than optimal. Subjects were asked to estimate how often they ate certain foods and the researchers converted this frequency of consumption into typical portion sizes and then into fat content. A more accurate method would have been observing actual food intake, but this would be impossible for such a large number of subjects. The large number of women included was a strong point of this study and probably improved its accuracy.

Health aspects, Research, Breast cancer, Cancer, Diet, Precancerous conditions, Diet in disease, Fat, Fats, Fibrocystic breast disease

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The effect of diagnosis and treatment delay on prognostic factors and survival in endometrial carcinoma

Article Abstract:

Moderate delays in diagnosis and treatment of endometrial cancer may not result in higher mortality rates. Endometrial cancer affects the inside layer of the wall of the uterus. Researchers found that for 181 patients with delays in diagnosis of up to a year from the onset of symptoms, the five-year survival rate was comparable to that of women with minor diagnostic delays. Most of the women (81.2%) were over 50, and postmenopausal bleeding was a frequently reported first symptom. A delay from diagnosis of cancer to treatment of up to four months did not seem to affect survival. Endometrial cancer may be a slow-growing cancer, and this may explain why delays in treatment do not result in higher mortality rates.

Prognosis, Endometrial cancer

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Comparison between primary peritoneal and epithelial ovarian carcinoma: a population-based study

Article Abstract:

A study was undertaken to characterize the primary peritoneal carcinoma (PPC) compared with ovarian carcinoma (OvC). The result indicates that clinical differences do not enable a preoperative distinction between the neoplasms.

United States, Case studies, Comparative analysis, Ovarian cancer, Tumors, Tumours, Digestive system diseases, Peritoneal diseases

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