Observational studies of drug safety--Aprotinin and the absence of transparency

Article Abstract:

The controversial discussions over aprotinin provide insight into the strengths and weaknesses of using observational data to assess drug safety and highlight the importance of using a transparent and open process when reviewing such data. After reviewing all the data available, it was decided that there was insufficient evidence to require an additional warning on aprotinin's labeling and it was agreed that the clinical data supported an acceptable safety and efficacy profile for aprotinin.

General services, Safety and security measures, Drug overview, Aprotinin (Medication)

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Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

Article Abstract:

A study was conducted to evaluate dasatinib, a BCR-ABL inhibitor that targets most imatinib-resistant BCR-ABL mutations, in patients with chronic myelogenous leukemia (CML) or Ph-positive acute lymphoblastic leukemia (ALL). It was found that dasatinib induces hematologic and cytogenetic responses in patients with CML or Ph-positive ALL who could not tolerate or are resistant to imatinib.

Evaluation, Chronic myeloid leukemia, Imatinib mesylate

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A single cycle of rituximab for the treatment of severe pemphigus

Article Abstract:

The efficacy of a single cycle of rituximab in severe types of pemphigus is assessed. The results have shown that a single cycle is an effective treatment for pemphigus, but its use should be limited to the most severe types of the disease due to its potentially severe side effects.

Dosage and administration, Pemphigus, Rituximab, Clinical report

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