Old approach yields new antibiotic

Article Abstract:

A new antibacterial compound with an astoundingly nefarious mechanism of action is introduced revealing that compound acts by removing the stringent controls on a bacterial protease, ClpXP, unleashing the enzyme to degrade cellular proteins in an unregulated manner. The parent compound was originally isolated from the culture broth of Streptococcus hawaiiensis, highlighting the value of natural product compounds and of mining the patent literature.

---

Multi-targeting by monotherapeutic antibacterials

Article Abstract:

A study discusses the distinguishing quality of the existing targets of monotherapeutic antibacterials, with their low potential for rapid endogenous resistance development that appears to be based on their capacity to act at multiple targets. It is suggested that ensuring multiple drug-target interactions, whether intra- or intermolecular, would be the key to overcoming endogenous resistance potential.

Drug resistance

---

The business of developing antibacterials

Article Abstract:

The antibacterial R&D business is in the midst of an unglamorous comeback born from medical necessity as well as from the steady rise of antibiotic-resistant pathogens that dictates a need for new products. New versions of familiar antibacterials are expected to keep the worst bacterial pathogens at bay until something truly amazing comes along to deliver a more substantial setback to the pathogens.

Drug therapy, Bacteria, Pathogenic, Pathogenic bacteria, Drug overview

Similar abstracts:

• Abstracts: Old is not the same as ill health. Challenging ageist attitude. Strategies to enhance privacy and dignity in care of older people
• Abstracts: The truth about gaining age. The science of exercise
• Abstracts: The new breed of students. The benefits of team training. Government pledges stroke training cash
• Abstracts: The special needs of children receiving intravenous therapy. Venepuncture
• Abstracts: Nurses should be ready to give bereavement care. The use of research findings in nursing practice. Clinical: Preventing and reporting drug administration

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.