Omeprazole to prevent recurrent bleeding after endoscopic treatment of ulcers

Article Abstract:

Omeprazole may be effective in preventing peptic ulcers from re-bleeding. Many patients with a bleeding ulcer are treated successfully with drugs or surgery, but the ulcer can re-bleed. This may happen because blood clots will only form at a pH of 6 or more. Below that, the clot will dissolve. Since the pH of stomach acid is below 6, blood clots may not form properly. Omeprazole may reduce stomach acid consistently enough to allow blood clots to form so the ulcer will heal. In a study published in 2000, the re-bleeding rate was substantially lower in patient who received omeprazole compared to a placebo.

Editorial, Prevention, Gastrointestinal bleeding, Gastrointestinal hemorrhage

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A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs

Article Abstract:

The antiulcer drug omeprazole appears to be more effective than ranitidine in treating ulcers in people on non-steroidal anti-inflammatory drugs (NSAIDs). Researchers randomly assigned 541 patients taking NSAIDs to 20 or 40 milligrams of omeprazole or 300 milligrams of ranitidine every day. Patients who responded to either drug continued to take it. About 80% of the patients taking omeprazole were successfully treated, compared to 63% of those taking ranitidine. Omeprazole was also more effective than ranitidine during long-term use.

Complications and side effects, Nonsteroidal anti-inflammatory drugs, Nonsteroidal anti-inflammatory agents, Ranitidine

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Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs

Article Abstract:

The antiulcer drug omeprazole appears to be as effective as misoprostol and has fewer side effects. Researchers randomly assigned 935 patients who had ulcers from taking non-steroidal anti-inflammatory drugs to take misoprostol or one of two dosages of omeprazole. By eight weeks, about 70% of all three groups had evidence of ulcer healing. Omeprazole was linked to a longer remission compared to misoprostol. More patients taking misoprostol had side effects during treatment.

Misoprostol

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