Oral tocolysis with magnesium chloride: a randomized controlled prospective clinical trial

Article Abstract:

Because prematurity is the major cause of death during the perinatal period (the time span covering late pregnancy and early infancy) death, much effort is aimed at preventing premature deliveries. Many agents, such as magnesium sulfate and adrenaline-related drugs (tocolytics), are used to arrest uterine contractions. However, the effectiveness of these tocolytic agents in preventing premature deliveries is unclear. Intravenous magnesium sulfate is often used as the initial agent in treating early uterine contractions, but its side effects on the digestive tract have usually prevented oral use. However, a new coated form of magnesium chloride, SLOW MAG, is available as a supplement in the US, and the effect of the oral drug on the outcome of 75 pregnancies was evaluated. After stabilization of an episode of preterm labor with intravenous magnesium sulfate, patients were divided into three groups, 25 in each. Group one received ritodrine (an adrenaline-like drug), group two received oral magnesium chloride, and group three was kept under observation only. The time gained between initial preterm labor and delivery did not differ among groups. There was a nonsignificant trend among the patients under observation who were taking no medication to have more recurrent episodes of preterm labor (56 percent) than those taking medications (48 and 44 percent). Patients with dilated cervixes at the onset of preterm labor gained less time and were more apt to have recurrent preterm labor. Patients taking ritodrine had significantly higher pulse rates, and 48 percent had side effects such as nervousness or palpitations. Twenty percent of patients taking magnesium had side effects such as nausea or diarrhea. The study indicates that oral magnesium and ritodrine do not differ in their ability to prolong pregnancy, and neither drug was more effective than close observation. (Consumer Summary produced by Reliance Medical Information, Inc.)

Evaluation, Product/Service Evaluation, Prevention, Drug therapy, Premature labor, Chlorides, SLOW MAG (Medication)

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The role of human papillomavirus deoxyribonucleic acid assay and repeated cervical cytologic examination in the detection of cervical intraepithelial neoplasia among human immunodeficiency virus-infected women

Article Abstract:

HIV-infected women may have a higher risk of cervical intraepithelial dysplasia, which is a precursor of cervical cancer. This may be due to the immunosuppression caused by HIV, which in turn increases the risk of papillomavirus infection.

Causes of, Cervix dysplasia, Complications

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Vaginal infections in human immunodeficiency virus-infected women

Article Abstract:

Women with HIV infection have a higher risk of vaginal infections, including bacterial vaginosis, vaginal candidiasis, and Trichomonas infection. This was the conclusion of a study of 159 HIV-infected women and 144 health women.

Complications and side effects, Risk factors, Candidiasis, Vaginosis, Trichomoniasis

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