The effect of antibodies and immunotoxins reactive with HER-2/neu on growth of ovarian and breast cancer cell lines

Article Abstract:

The use of anti-p 185 monoclonal antibodies and an anti-p 185 immunotoxin may inhibit the expression of the gene HER-2/neu in ovarian and breast cancer cells. HER-2/neu is thought to play a role in growth regulation. Its over-expression is seen in 25% to 30% of breast and ovarian cancers and is associated with reduced survival in these cancers. Ovarian and breast cancer cells that express HER-2/neu were grown in culture and treated with various monoclonal antibodies and immunotoxins. The anti-p 185 antibody ID-5 blocked growth of one type of breast cancer cell and two types of ovarian cancer cells by 45% to 50%. The TA-1-ricin immunotoxin significantly inhibited the cloning of one type of breast cancer cell and one type of ovarian cancer cell. Further studies are needed on whether these immunotherapy techniques can impair breast and ovarian cancer growth in the body.

Research, Prevention, Genetic aspects, Breast cancer, Ovarian cancer, Monoclonal antibodies, Gene amplification, Immunotherapy

---

Preoperative evaluation of macrophage colony-stimulating factor levels in patients with endometrial cancer

Article Abstract:

Blood levels of macrophage colony-stimulating factor (CSF) and of CA 125 may not be adequate preoperative indicators of metastatic cancer outside the uterus in women with uterine cancer. Macrophage CSF and CA 125 are secreted by tumors. Researchers analyzed blood samples from 92 women who had surgery to remove endometrial cancer. Cancer was contained within the uterus in 74 (80%) of the women, while 12 women were found to have cancer that had metastasized outside the uterus. Blood levels of macrophage CSF were less sensitive than CA 125 levels at predicting metastatic cancer outside the uterus. Blood levels of both indicators combined positively predicted 68% of extrauterine cancers, and correctly predicted no extrauterine cancer at a rate of 78%.

Diagnosis, Measurement, Physiological aspects, Endometrial cancer, Metastasis, Cancer metastasis, Macrophage colony stimulating factor

---

Similar abstracts:

• Abstracts: The relative risk of incident coronary heart disease associated with recently stopping the use of beta-blockers. part 2
• Abstracts: In vivo antinuclear antibody of the skin: diagnostic significance and association with selective antinuclear antibodies
• Abstracts: Management of endometrial cancer with suspected cervical involvement. Primary invasive carcinoma of the vagina
• Abstracts: Magnetic resonance imaging of neurohypophyseal germinomas. Endometrial cysts: diagnosis with MR imaging. Gallbladder carcinoma: evaluation with MR imaging
• Abstracts: A report on radiation-induced gliomas. Second cancer after radiation therapy for cancer of the uterine cervix

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.