Ovulaton induction in the poor responder or hyperresponder
Article Abstract:
Early recognition of poor responders or hyperresponders to ovulation induction (OI) may prevent wasted time, decrease the medical risks of gonadotropin therapy, and reduce the emotional and financial drain on couples undergoing fertility treatment. Couples for whom OI is ineffective may take advantage of assisted reproductive techniques (ART) or adoption. Clomiphene may be the first choice of adjunctive agents to OI, followed by menotropin or urofollitropin therapy. Ultrasound and E2 levels may be used to monitor the ovarian response and to decide whether an OI cycle should be cancelled in patients taking gonadotropins. "Low and slow" regimens, using small initial doses of urofollitropin, may be used in patients who have failed cycles of gonadotropin therapy. Patients for whom OI does not work because they have large amounts of nondominant follicles or experience ovarian hyperstimulation may be candidates for ART. Women who are over 35, obese, have had ovarian surgery, or have had severe endometriosis may be poor responders to OI. Patients who are hyperstimulated by gonadotropin therapy may be allowed to "coast," or go off the therapy for a few days.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
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Laser vaporization of the ovarian surface in polycystic ovary disease results in reduced ovarian hyperstimulation and improved pregnancy rates
Article Abstract:
Laser surgery may reverse infertility associated with polycystic ovary disease in women. Polycystic ovary disease, or multiple cysts in the ovaries, typically blocks conception. Since hormone treatment of ovarian cysts often causes hyperstimulation of the ovaries, alternative surgery may be preferred. Researchers vaporized the cystic ovaries of 26 women who were unable to conceive. After the laser procedure, six patients ovulated normally and 23 women received hormone therapy consisting of clomiphene citrate or human menopausal gonadotropin. Only three patients in the human menopausal gonadotropin group developed mild forms of ovarian hyperstimulation. The overall rate of ovarian hyperstimulation dropped after laser vaporization. A total of 19 women became pregnant. Five patients conceived naturally, while chemically induced ovulation facilitated pregnancy in 14 women.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
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Optimal pregnancy outcome in a minimal-stimulation in vitro fertilization program
Article Abstract:
Minimal ovarian stimulation may be a cost-effective treatment for female infertility in women who cannot afford full treatment. Although the pregnancy rate is lower, there are fewer side effects and fewer cases of multiple pregnancy.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2000
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