Phencyclidine pharmacokinetics after a massive overdose

Article Abstract:

Phencyclidine (PCP), an hallucinogenic drug, is not generally used therapeutically and is a commonly abused drug. Since PCP is cleared from the body primarily through metabolism, eliminating it from the body is slow. It is not known how long it takes for the body to clear PCP. A 28-year-old man exhibiting bizarre behavior during an airline flight was sent to a mental facility where a urine test detected PCP. His mental state remained impaired and he was sent to a hospital for evaluation. He was given bromocriptine and dantrolene, which is used as treatment for neuroleptic syndrome, an altered state of consciousness. On the eighth hospital day, the patient had respiratory failure and required artificial respiration. A high temperature followed with a concurrent increase in blood pressure and heart rate. Seizures and muscle deterioration were noted. On the 11th hospital day two plastic bags filled with PCP, one of which was ruptured, were passed through his rectum. This was followed by neurological recovery and the patient was subsequently released with mild neurological sequelae. It took 12.5 hours from the passage of the bags for half of the PCP to be eliminated from the body. This was the highest level of PCP ever recorded in a survivor. (Consumer Summary produced by Reliance Medical Information, Inc.)

Health aspects, Phencyclidine

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Effects of the antacids in didanosine tablets on dapsone pharmacokinetics

Article Abstract:

The antacids contained in most preparations of didanosine apparently do not adversely interact to reduce the blood levels of dapsone when patients with human immunodeficiency viral (HIV) infections take these drugs together. Physicians monitored the blood levels of dapsone in 6 patients with HIV taking both dapsone and didanosine therapies (study group) and 6 healthy volunteers taking dapsone and didanosine placebo therapy (control group). First, the two treatment groups took one cycle of dapsone alone. Three weeks later the control group took two doses of didanosine placebo, then a combination dapsone and didanosine dose, followed by a final didanosine placebo dose. The study group followed the same dose cycle. However, the study group took the combination didanosine and dapsone dose after 26 doses of didanosine. Dapsone blood level measurements did not significantly differ when taken with the didanosine-antacid medication as compared to when the groups took dapsone alone.

Analysis, Physiological aspects, HIV infection, Drug therapy, HIV infections, Drug interactions, Dapsone, Antacids, Didanosine

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Acute Heroin Overdose

Article Abstract:

Acute heroin overdose causes altered mental state, decreased breathing, unresponsive pupils, and death. Patients who overdose on heroin are frequently using alcohol or other drugs simultaneously, and often in the company of others. Overdose requires respiratory support and treatment with naloxone, a narcotic antagonist. A methadone maintenance program can facilitate heroin withdrawal and prevent overdose.

United States, Complications and side effects, Narcotics, Heroin habit, Overdose

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